USE OF ANTIBODY-DRUG CONJUGATES AND ANTIBODIES FOR DRUG DELIVERY

An antibody-drug conjugate composed of a drug and an anti-HMGB1 antibody that enables to selectively deliver the drug to proangiogenic or hyperpermeable vascular endothelial cells, as well as to brain tissues.

An antibody-drug conjugate composed of a drug and an anti-HMGB1 antibody that enables to selectively deliver of the drug to proangiogenic or hyperpermeable vascular endothelial cells, as well as to brain tissues.

Abstract

One purpose of the present invention aims to provide a novel drug delivery means for targeting neovascularity. Another purpose of the invention is to provide a novel drug delivery means for targeting hyperpermeable vasculature. Still another purpose of the invention is to provide a method and a detection reagent for the treatment or diagnosis of various diseases including malignant tumors. The present conjugate of a drug and an anti-HMGB1 antibody or an antigen-binding fragment thereof is administered to a subject and incorporated into proangiogenic or hyperpermeable vascular endothelial cells to deliver the drug to the cells. In addition, the conjugate is used to provide a method and a detection reagent for the treatment or diagnosis of various diseases including malignant tumors.

Website

http://www.okayama-u.ac.jp/index_e.html