Universal Sensor for Virus Detection Based on Glycopolymer Capture Agents

Rapid, self-administered alternative to time-consuming PCR tests Modular, reconfigurable detection platform suited for other viral and non-viral pathogens and emerging variants Use of glycopolymer capture agents lowers material and development costs re…
  • Rapid, self-administered alternative to time-consuming PCR tests
  • Modular, reconfigurable detection platform suited for other viral and non-viral pathogens and emerging variants
  • Use of glycopolymer capture agents lowers material and development costs relative to current LFSAs.

Abstract:

The present invention is a lateral flow strip-based assay (LFSA) for the visual detection of viruses, related antigens, and emerging variants. This platform uses glycopolymer capture agents, in combination with antibodies labeled with gold nanoparticles, to generate a visual result in under 30 minutes. The non-specific nature of the glycopolymer capture agent renders the sensor platform generalizable and readily adaptable to selected virus families and mutant strains when paired with an appropriate antibody. In its current form, this platform enables the selective, naked-eye detection of SARS-CoV-2 spike glycoproteins in complex mixtures containing unrelated betacoronavirus antigens and biologically-relevant proteins commonly found in patient samples. The platform also provides visual detection of SARS-CoV-2 variants Alpha, Beta, and Delta, demonstrating the universality of glycopolymer capture agents. Its ability to detect SARS-CoV-2 spike protein in spiked samples of human saliva further demonstrates the platform’s potential for future clinical and consumer use.

Website:

https://unc.flintbox.com/technologies/8D93C149171B4606A96C5C906573D0BD

Additional Information:

Publications

GlycoGrip: Cell Surface-Inspired Universal Sensor for Betacoronaviruses | ACS Central Science

Other

Sugar-coated COVID-19 test takes advantage of coronavirus’ sweet tooth - UNC News : UNC News

Intellectual Property

Number: Provisional Application
Status: filed

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