Suspension-based Oral Solid Doses

  • TRL
  • 4

Abstract

Oral solid doses constitute approximately 60% of drug products. Oral solid dose manufacturing must deal with challenges associated with powder rheology; this is problematic for micronized powders which are cohesive. Poorly water-soluble compounds constitute 40% of currently marketed compounds. Particle size reduction is used to improve drug bioavailability but causes rheological problems in manufacturing. The lack of constitutive equations leads to a demand for an effective precision dosing process. Researchers at Purdue University have developed a new micron-scale powder process. This process enables accurate dosing of drug mass and low product relative standard deviation; additionally, the method allows for the specification of particle size distribution in a product by choice of source material, as experiments have demonstrated that particle size is preserved through the printing process. Advantages: -Versatile processing of fine particles -Low relative standard deviation -Enables production of high-dose pharmaceuticals Potential Applications: -Compounding pharmacy -Slurry printing

Website

https://prf.flintbox.com/technologies/5C16D96399A746BC948789CBCA401DF5

Advantages

-Versatile processing of fine particles-Low relative standard deviation-Enables production of high-dose pharmaceuticals

Potential Applications

-Compounding pharmacy

-Slurry printing

Contact Information

Name: Joseph R Kasper

Email: JRKasper@prf.org

Phone: 765-588-3475