Rapid 3D-Bioprinting of Vascular Tissue Models for Drug Discovery

  • Can be rapidly manufactured in a day
  • More accurate in-vitro modeling than existing PDMS-based models
  • Effective for small-molecule drug testing

Abstract

Preclinical drug studies typically rely on animal experimentation. However, due to the decreasing drug attrition rate, new cell culture models, known as microphysiological systems (MPSs) or organs-on-chips (OOCs), have been developed for preliminary drug testing. MPSs allow for the recreation of human tissue-tissue interfaces, and consist of a base material containing hollow microchannels populated by living cells. However, most use polydimethylsiloxane (PDMS) scaffolds and membranes, leading to numerous disadvantages. They take weeks to create, and are ineffective for drug testing because small molecules are absorbed by the PDMS material. Additionally, intercellular interactions are limited because the membrane creates asymmetrical, inaccurate formations of the tissue-tissue interfaces. A more accurate and less time-consuming method of creating these models is needed. Dr. Riccardo Barrile and his team have developed a new method for creating accurate vascular tissue models without the use of PDMS. This method combines industrial 3D printing techniques with 3D-bioprinting methods to create scalable, accurate, and cost-effective models for preliminary drug testing, often in a single day.

Website

https://uc.flintbox.com/technologies/E33A81EF621B4150BD17F0278F25A16C

Contact Information

Name: Madison Bourbon

Email: bourbomn@ucmail.uc.edu

Phone: 513-558-4237