Production of Resolvins from Fatty Acid-loaded Liposomes to Treat Inflammatory Diseases

Unmet Need: Targeted treatment for inflammatory diseases Inflammation is an immune response usually caused by trauma or infection. When dysregulated, inflammation can cause diseases such as acute lung inflammation (ALI) leading to acute respiratory di…

Unmet Need: Targeted treatment for inflammatory diseases

Inflammation is an immune response usually caused by trauma or infection. When dysregulated, inflammation can cause diseases such as acute lung inflammation (ALI) leading to acute respiratory distress syndrome (ARDS). There are over 200,000 cases of ARDS annually in adults in the United States, however, there are no approved therapeutics for this disease.

The Technology: Targeted delivery of resolvin precursors to resolve inflammation without suppressing the immune response

The inventors have developed a lung-targeted therapeutic utilizing omega-3 fatty acids which metabolize to resolvins to treat acute inflammation, specifically ALI/ARDS. Resolvins are a type of biomolecule that help resolve inflammation in tissue, as opposed to suppressing immune response. Unfortunately, they are difficult to synthesize and sensitive to oxidation. The inventors have developed a method to deliver a resolvin precursor, docosahexaenoic acid (DHA), to inflamed lung tissue where it is metabolized to resolvins. The treatment utilizes newly designed liposomes, loaded with DHA and coated with a neutrophil-targeting antibody to specifically target activated neutrophils in vivo.

Applications:

  • Treatment of inflammation
  • Acute lung inflammation and

acute respiratory distress syndrome treatment

Advantages:

  • Targeted delivery reduces side effects
  • Does not suppress the immune response
  • In vivo production of resolvins reduces degradation

Patent Information:

Provisional patent filed

Website:

https://wsu.technologypublisher.com/technology/46099

Contact Information:

TTO Home Page: https://wsu.technologypublisher.com

Name: Scott Steiger

Title: Assistant Director

Department: Office of Commercialization

Email: scott.steiger@wsu.edu

Phone: (509) 335-7065