Precision-structured surface functionalization of hydrogels

  • The researchers found that the functionalized surface patterns interactions with DNA at the interface, a capability of importance for chromatography, supports, and implants.

Abstract

Researchers at Purdue University have developed a method to produce a highly-structured functionalized hydrogel surface. Traditionally, polyacrylamide (PAAM) hydrogels cross-linked with bis-acrylamide have been used as functionalized surfaces for DNA chromatography, cell culture supports, and implants for regenerative medicine. However, surface heterogeneity of these surfaces creates unpredictable interactions with biomolecules. The Purdue researchers’ method involves assembling nanometer-resolution chemical functional patterns on highly oriented pyrolytic graphite (HOPG), polymerizing them to ‘set’ the functional pattern, and then transferring the functional pattern to PAAM. This method creates a highly-structured pattern that provides predictable assembly of nano- and microscopic objects at the interface. Technology Validation: The researchers found that the functionalized surface patterns interactions with DNA at the interface, a capability of importance for chromatography, supports, and implants.

Website

https://prf.flintbox.com/technologies/6B966B3AFBA5474C83779C6D41B795EC

Advantages

  • highly-structured surface
  • predictable interactions with biomolecules

Potential Applications

  • DNA chromatography
  • Cell culture supports
  • Implants for regenerative medicine

Contact Information

Name: Dipak Narula

Email: DNarula@prf.org

Phone: 765-588-1062