NOVEL MONOCLONAL ANTIBODIES HAVING ANTI-INFLAMMATORY ACTION

This technology relates to a novel monoclonal antibody having an anti-inflammatory action.

This technology relates to a novel monoclonal antibody having an anti-inflammatory action.

Abstract

Provided is a more effective anti-inflammatory agent having fewer side effects as compared to NSAIDs and steroidal anti-inflammatory agents. A therapeutic agent for inflammatory diseases containing as an active ingredient an anti-4-HNE antibody, which inhibits 4-HNE, has been found to have ameliorating effects on the expressions of various inflammation markers involved in cerebral infarction and cerebral ischemia-reperfusion and has also been found to have life-prolonging and life-saving effects in sepsis model animals. The anti-4-HNE antibody shows remarkable efficacy even on inflammatory diseases on which existing anti-inflammatory drugs, such as NSAIDs and steroidal anti-inflammatory agents, have hitherto not shown effects.

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