UCLA researchers have developed a method to generate uniform emulsions composed of small droplets formed through the action of mixing shaped microparticles with an oil and water solution. These droplets maintain a monodisperse state allowing for equal dispersion of their contents. This allows for these droplets to easily contain uniform amounts of the desired material and creates a predictable and reliable system for e.g. molecular or cellular analysis. In addition, due to the unique construction of these particles, the formation of an outer and inner layer allows for unique properties to be assigned depending on each layer’s content. Each compartment is chemically-defined and can be sized to hold only a single particle or cell, allowing for digitized solid substrates that can be barcoded for single-cell analysis to store information from reactions or impart new physical properties.
UCLA researchers in the Departments of Bioengineering and Mathematics have developed a method to generate uniform, thermodynamically stabilized microdroplets with digitizable solid structures.
- Creates uniform drops
- Thermodynamically stabilized microdroplets
- Interior and exterior can be chemically modified separately
- Digitized solid structure
- Easily applied to multiple sources
- Microscale drop-carrier particles
- “Lab-on-a-particle” technologies
- Single-Molecule Analysis
- Small Droplet Laboratories
- Small Volume Devices
Name: UCLA Technology Development Group