Dendronized Polymer Vectors For siRNA Delivery

RNAi has tremendous potential for therapeutic treatment. However, the lack of safe and efficient intracellular delivery vectors has significantly hampered the potential of siRNA technology. The new invention involves a polymer platform for siRNA deliv…

RNAi has tremendous potential for therapeutic treatment. However, the lack of safe and efficient intracellular delivery vectors has significantly hampered the potential of siRNA technology. The new invention involves a polymer platform for siRNA delivery. This novel architecture allows for successful intracellular delivery and optimal siRNA binding. The versatile structure could be tuned to select optimal vectors, and several structures have been identified to effectively deliver siRNA to cells in vitro and exhibit minimal toxicity. The combination of high delivery efficiency in serum and low cytotoxicity suggests the system as a promising new carrier for siRNA delivery.

Abstract:

Researchers at the University of California, Irvine have developed a new medium for delivery of siRNA genetic materials into cells. This medium is a vector, and its architecture allows for optimal siRNA binding. RNAi has tremendous potential for therapeutic treatment, and this vector allows for safe and efficient intracellular delivery of siRNA.

Website:

https://techtransfer.universityofcalifornia.edu/NCD/24058.html?utm_source=AUTMGTP&utm_medium=webpage&utm_term=ncdid_24058&utm_campaign=TechWebsites

Advantages:

RNAi has tremendous potential for therapeutic treatment. However, the lack of safe and efficient intracellular delivery vectors has significantly hampered the potential of siRNA technology. Current viral-based vectors have serious concerns of immunogenicity and infection. Current synthetic vectors are often toxic to cells and generally of low efficiency in gene knockdown. The invented carriers have lower cytotoxicity and higher efficiency for siRNA delivery, making this system a promising new carrier for siRNA delivery.

Potential Applications:

This technology can be used to safely and effectively delivery siRNA into cells.

Contact Information:

नाम: Richard Tun

ईमेल: tunr@uci.edu

फ़ोन: 949-824-3586