BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV

­ Application ELISA Western Blot Immunohistochemistry Specficity HIV-1 BG505 Env protein (clone name: YRK01, YRK02). Subtype Monoclonal antibody. Immunogen HIV-1 BG505 SOSIP Env trimer. Technical Summary HIV-1 envelope glycoprotein (…

Application

  • ELISA
  • Western Blot
  • Immunohistochemistry

Specificity
HIV-1 BG505 Env protein (clone name: YRK01, YRK02).

Subtype
Monoclonal antibody.

Immunogen
HIV-1 BG505 SOSIP Env trimer.

Technical Summary
HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells that allows the virus to enter cells. Emory researchers have identified two clonally related monoclonal antibodies that were recovered from a BG505 SOSIP immunized rhesus macaque via PCR and cloning of the immunoglobulin heavy and light chain variable domain gene segments from single antigen-specific B cells. The monoclonal antibodies potently neutralize the autologous BG505 envelope pseudovirus (a virus that infects susceptible cells but only replicates once). This can be used as a research tool to generate neutralizing antibodies against HIV.

Publication: Ward and Wilson, Trends in Biochemical Sciences, 2015 Feb;40(2):101-7

Site Internet

https://emoryott.technologypublisher.com/techcase/20045

Coordonnées

Page d'accueil du BTT : https://emoryott.technologypublisher.com

Nom: Sat Balachander

Titre: Licensing Associate

E-mail: sbalac5@emory.edu

Téléphoner: (404) 727-4968