Treating fluoroacetate poisoning through stabilization of hypoxia-inducible transcription factor

  • Fluoroacetate poisoning is often fatal with no reliable antidote.
  • Novel compound stabilizing HIF-1a can rescue cell death caused by fluoroacetate.

Abstract
Exposure to fluoroacetate (FA) causes a spectrum of cardiac, respiratory, neurological, and metabolic dysfunctions that can be fatal. Currently there is no reliable antidote and rescue options are limited to ethanol administration that is partly effective only when given immediately following exposure. Dr. Aftab Ahmad has identified a novel chemical compound to stabilize the transcription factor HIF-1a to prevent cell death in FA poisoning.

Contact Information

Name: Francis T Crittenden

Email: ftgcritt@uab.edu

Phone: (205) 975-6851