Therapeutic Peptide-based Inhibitor of Nox1 NADPH Oxidase

Abstract:

Researchers have invented a short peptide that interferes with the phosphorylation of Nox1 and prevents its association with other co-factor proteins that are needed for its activation. The net effect is that this peptide “turns off” Nox1, resulting in decreased ROS production and abrogation of ensuing pathogenic phenotypes. Therefore, this peptide has potential to be used as a novel drug to block Nox1 activity in a variety of disease settings.

Website:

https://uiowa.flintbox.com/technologies/B66FCCB5382449F299BB81D02DF3ED5B

Advantages:

▪ Novel Inhibitory Peptide - Prevents docking of the protein cofactors that are necessary for (Nox1) NADPH oxidase activity.
▪ Potential applications in the treatment of Hypertension, Atherosclerosis and Cancer.