Targeting genomic DNA for cancer therapy

  • Platform technology for targeting genomic DNA to inhibit the transcription of oncogenes
  • In vitro and in vivo studies shows significant downregulation of oncogene at mRNA and protein levels and reduced tumor growth
  • Chemically modified PNA with small molecule inhibitors improves functional activity due to the higher accessibility of PNA at the target genomic location

Contact Information

Name: Amit Kumar

Email: a.kumar@uconn.edu

Phone: (860) 486-6938