T-Cell Exhaustion State-Specific Gene Expression Regulators And Uses Thereof


T cell exhaustion occurs with state-specific regulation of genes critical to their dysfunction. These state-specific genomic regulators of gene expression are targets for modulation, such as by genomic editing, for altering gene expression preferentially in exhausted CD8+ T cells or in cells affecting T cell function. Selectively targeting T cell exhaustion-specific genomic regulatory elements, such as enhancers, suppressors, and promoters, can maintain normal physiological regulation of genes like PD-1, while. Preventing the development of T cell exhaustion may be therapeutic in cancer and/or viral infections.




One can engineered a mammalian T cell comprising a genomic region that regulates the gene expression of exhausted CD8+ T cell from the mammal where the genomic region is genetically modified and the genetic modification modulates the expression of the gene.

Potential Applications

It may be beneficial when a human i afflicted with an immune disorder such as chronic infection or cancer.

Contact Information

Name: Craig Kennedy

Email: craig.kennedy@berkeley.edu