SYSTEMS AND METHODS FOR CONDUCTING NEUTRAL LOSS SCANS IN A SINGLE ION TRAP

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Abstract
Researchers at Purdue University have developed a computer program to control a table-top mass spectrometer using a linear ion trap. Generally, mass spectrometers are only capable of analyzing the fragments arising from a single precursor ion at a time. By scanning an excitation function and applying simultaneously an ejection waveform at a frequency corresponding to a mass-to-charge ratio (m/z) associated with loss of a neutral fragment, the Purdue researchers’ approach allows analysis of multiple ions at once. The approach also minimizes interferences. This technique of waveform generation can open new frontiers in chemical analysis. Technology Validation: Neutral loss scans connecting two m/z values clearly distinguished four amphetamines from other compounds in a mixture of illicit drugs. Advantages – Efficient – Simple – Low power Applications – Mass spectrometry – Chemical analysis – Linear ion traps

Contact Information

Name: Dipak Narula

Email: DNarula@prf.org

Phone: 765-588-1062