System for Transcatheter Grabbing and Securing the Native Mitral Valve’s Leaflet to a Prosthesis

Left ventricular outflow tract (LVOT) obstruction is a leading cause of mortality and exclusion from transcatheter mitral valve replacement (TMVR). LVOT obstruction is a frightening TMVR complication, occurring in up to 40% of valves implanted in a native mitral annular calcification, 5% of valve-in-ring cases, and 2% of valve-in-valve cases. Potential for LVOT obstruction is the most important cause for patient exclusion for TMVR, with 49% of patients for valve implants in a native mitral annular calcification and 6% of patients for valve-in-ring excluded for TMVR due to predicted risk of LVOT obstruction.

There are two mechanisms that lead to TMVR-induced LVOT obstruction: (1) Static obstruction occurs when the native mitral valve’s anterior leaflet is pushed toward the interventricular septum by the mitral valve prosthesis, creating a narrowed and elongated “neo-LVOT;” (2) Dynamic obstruction occurs when the narrowed neo-LVOT generates Bernoulli forces that pulls the anterior mitral leaflet toward the interventricular septum during systole. A long anterior mitral leaflet with redundant chordae could be a risk factor which may also prolapse back into the transcatheterly-implanted mitral valve, interfering with valve closure and causing acute valve failure.

As a solution to avoid both static and dynamic TMVR-induced LVOT obstruction, researchers at UC Irvine have developed an assembly of components that work together as a system for first grabbing, and then securing the native mitral valve’s leaflet to a prosthesis via transcatheter means.

Abstract
Researchers at UC Irvine have developed an assembly of components that work together as a system for first grabbing, and then securing the native mitral valve’s leaflet to a prosthesis via transcatheter means.

Website

https://techtransfer.universityofcalifornia.edu/NCD/32960.html?utm_source=AUTMGTP&utm_medium=webpage&utm_term=ncdid_32960&utm_campaign=TechWebsites

Advantages

·To avoid both static and dynamic transcatheter mitral valve replacement (TMVR)-induced left ventricular outflow tract obstruction (LVOT)

Potential Applications

·To avoid both static and dynamic transcatheter mitral valve replacement (TMVR)-induced left ventricular outflow tract obstruction (LVOT)

Contact Information

Name: Alvin Viray

Email: aviray@uci.edu

Phone: 949-824-3104