Specifically Targeted Binders and Antimicrobial Peptides (STAMPs) to Control Candidatus Liberibacter spp.

  • Designed to specifically target and inhibit or kill C. Liberibacter spp. or related bacteria
  • Enhanced Efficacy and/or durability of therapeutic effect
  • May be deployed as therapies or prophylactic

Abstract

Several fastidious (unculturable) plant pathogens such as the vascular-limited Candidatus Liberibacter spp., presumptive causal agents of Huanglongbing (HLB or citrus greening) and potato zebra chip disease are devastating to agriculture. Due to their recalcitrance to conventional laboratory culturing techniques, specialized lifestyles and colonization limited to the plant vasculature, deployment of therapies that can effectively control these pathogens is challenging. Researchers at Texas A&M AgriLife Research and the University of California -Riverside have designed and developed specifically targeted peptides that can bind and/or inhibit Candidatus Liberibacter spp. The binders can also enhance the persistence and/or efficacy of any linked antimicrobial peptides (AMPs) in planta. This invention was created around the development of (i) C. Liberibacter binders, (ii) the specific amino acid (including modified amino acids) sequences of the specifically targeted antimicrobial peptides (STAMPs) including the three key elements – which are the C. Liberibacter binders, the linkers, and the antimicrobial peptides, (iii) the specific order of the three key elements, (iv) the specific compositional combinations of the three key elements and, (v) their derivatives.

Contact Information

Name: Jennifer C Souter

Email: jesouter@ttu.edu

Phone: 806-834-7507