SMALL MOLECULES AS DUAL RECEPTOR LIGANDS FOR CANCER CHEMOTHERAPY & IMMUNOTHERAPY

  • Potential first-in-class therapy to treat multiple cancers targeting growth, survival, and mitigation/invasion pathways and genes in cancer cells and tumors
  • Potential viable, non-hormonal therapy for endometriosis

Abstract

Scientists at Texas A&M have synthesized new small molecule compounds, called C-DIMs, which directly modulate the activity of one or more nuclear receptors, NR4A1 and/or NR4A2. These receptors have been shown to be primary factors in several inflammatory diseases, including many forms of cancer and endometriosis. The C-DIMs have demonstrated the ability to inhibit cell growth and to induce apoptosis in several forms of tumor cells. Our scientists have also shown, in vitro and in vivo, the potential of these compounds to be efficacious in treating endometriosis through many of the same mechanisms.

Contact Information

Name: Janie C Hurley

Email: jhurley@tamu.edu

Phone: (979) 845-6337