SAGE: A Self-Administered Test to Detect Signs of Mild Cognitive Impairment, Alzheimer’s, and Dementia

T2011-143 SAGE, Self-Administered Gerocognitive Examination, is a test used for early identification of mild cognitive impairment (MCI) to identify patients or research participants with symptoms of Alzheimer’s or other dementia-related diseases.

Abstract
The Need

Patients benefit from early-stage treatment strategies that can slow the progression of dementia-related diseases. Other methods are unable to differentiate normal aging from MCI, but it is important to distinguish between the two since patients most benefit from early-stage treatments. Therefore, there is an immense need for a cognitive assessment tool that screens/case finds individuals to identify MCI and early-stage dementia-related diseases.
The Technology

The SAGE test, developed by Ohio State neurologist Dr. Douglas Scharre, is a self-administered assessment tool that can be downloaded, printed, and taken via pen to paper. This allows examination at a person’s home, in a physician’s office, or virtually anywhere. SAGE identifies cognitive impairment in its earliest stages. By detecting subtle cognitive impairments and being sensitive to changes over time, SAGE differentiates normal aging from MCI. Early identification of cognitive impairment makes it easier to find research participants at early and pre-dementia stages to evaluate research therapies.

Commercial Applications

  • Early patient identification for further evaluation of symptoms
  • Research participant identification for clinical trials
  • Identification of post-treatment cognitive changes over time

Benefits/Advantages

  • Able to differentiate normal aging from MCI
  • Self-administration allows for convenient use when classifying patients and prescreening for drug trials
  • Identifies patients in early stage of disease to enhance the benefits of disease-modifying treatments
  • Provides a baseline for the future by detecting subtle cognitive impairments and being sensitive to changes over time
  • Average test taking time is only 10-15 minutes
  • Detects early dementia at least 6 months sooner than Mini-Mental State Examination (MMSE)

Publications