Progestins as treatment against dry age-related macular degeneration and disorders of the retinal pigment epithelium

The earliest manifestations of AMD are an accumulation of a yellow substance called drusen that is a cause of dysfunction of retinal pigment epithelium (RPE). RPE is a caretaker tissue responsible for the maintenance of the retina and dysfunction in RPE results in retina degeneration and blindness. The RPE relies on a specific set of ion channels, and one of them is indispensable for healthy RPE function. This channel is inwardly rectifying potassium channel Kir7.1.

UC Berkeley researchers have found compound(s) that activate Kir7.1 and is a novel therapeutical target to sustain normal RPE function.


Potential Applications

Development of eye-drop based supplementation to prevent the dry form of age-related macular degeneration (AMD) and prevent blindness.

Contact Information

Name: Terri Sale


Phone: 510-643-4219