Optical Control of Mitochondrial Metabolism

Background
Mitochondria are organelles found in most eukaryotic organisms and they are the powerhouse of the cell. Mitochondria generate an electrochemical proton gradient known as the protonmotive force (PMF). The PMF is like a battery, in that potential energy is stored for eventual release to do work. Mitochondrial dysfunction is implicated in a wide range of diseases and occurs when this organelle fails to produce enough energy for the body to function properly. In the US, mitochondrial diseases are known to annually affect 1 in 5,000 individuals. It is also estimated that 1,000-4,000 children are born with a mitochondrial disease every year, in the same region. Despite major advances in understanding the molecular mechanisms, currently, there are no effective treatments for the disease. The treatment of mitochondrial disorders is mostly performed with different vitamins, co-factors, off-label drugs approved for other indications, and nutritional supplements. Therefore, there is a current need for developing specific therapies for treating mitochondrial diseases.

Technology Overview
Optogenetics uses light-sensitive proteins to control biological functions and when targeted to mitochondria may allow rapid and precise manipulation of the PMF by controlled exposure to light. Researchers at Rochester have developed an optogenetic tool called mitochondria-ON (mtON) due to its ability to mimic the proton pumping activity in response to light, independent of oxygen or substrate availability. In animal models, mtON showed a significant increase in energy production bypassing the requirement for O2 consumption. Additionally, mtON is capable to reverse and control mitochondrial dysfunction and affects whole-animal energy-sensing. mtON’s ability to augment the PMF via optic control opens a new avenue for discovery in metabolic research.

Benefits
mtON represents a novel tool to control mitochondrial function through the use of light and presents an intervention point to treat disease and other negative phenomena.

Applications
Mitochondrial diseases and diseases where mitochondrial dysfunction is part of the pathology such as diabetes, Alzheimer’s disease and cancer.

Opportunity
Seeking to license the technology exclusively.

Patents

  • PCT application pending

Seeking

  • Licensing

IP Status

  • Patent application submitted
  • Abstract None

Website

http://rochester.technologypublisher.com/technology/47484

Contact Information

TTO Home Page: http://rochester.technologypublisher.com

Name: Matan Rapoport

Email: matan.rapoport@rochester.edu

Phone: 585.276.6600