Omni-Purpose, Scalable and Reusable Digital Microfluidic Platform with Dual Active-Matrix Circuitry

  • Novel digital microfluidic platform
  • Digital biochip has capability to control the movement and temperature of individual droplets

Abstract

This invention is a novel digital microfluidic platform for manipulating liquid droplets with unlimited freedom and scalability. It has the capability of manipulating thousands to millions of droplets simultaneously for large-scale chemical and biological analysis and synthesis. The digital biochip has the capability to control the movement of individual droplets while at the same time controlling the temperature of the droplet to assist the chemical and biological reaction inside the droplet. A droplet may be activated by an electrode positioned below the dielectric substance it is resting on, considerably decreasing the number of fluidic systems-based channels.

Advantages

  • Easily customized for specific tasks based on the needs of end-users
  • Can be reused and has low cost-of-ownership
  • Capable of achieving precise control of process conditions
  • Capable of handling millions of droplets simultaneously

Potential Applications

  • Genomic and proteomic analyses
  • Immunoassays
  • Single cell studies
  • Clinical diagnostics
  • Toxin and environmental monitoring including chemical and biological threat agent detection
  • New drug development
  • Fine chemical synthesis

Contact Information

Name: Shyamala Rajagopalan

Email: SRajagopalan@tamu.edu

Phone: 979-862-3002