A set of photographs showing inhibition of C. trachomatis by acylpyrazoline (Using compound 4)
Chlamydia trachomatis is the most common sexually transmitted pathogenic bacterium worldwide. If left untreated in women, this infection often leads to serious complications including infertility, pelvic inflammatory syndrome, ectopic pregnancy, and abortion. Several broad-spectrum antibiotics are used to treat diagnosed chlamydia. However, they also kill beneficial bacteria in the reproductive as well as the gastrointestinal tract, leading to dysbiosis. In addition, C. trachomatis may develop resistance to antibiotics. Thus arose the need to develop new selective antichlamydial compounds.
Rutgers researchers have developed five new selective antichlamydial ‘acylpyrazoline’ compounds with minimal inhibitory concentration. These compounds have about 2- to 5-fold higher potency in comparison to similar compounds and were designed to have better drug properties. Certain structural modifications show that these compounds are highly tolerated by bacteria colonized in humans. Studies show that all the five novel antichlamydial compounds are well tolerated by lactobacilli found in human vagina, E. coli in human gastrointestinal tract and other human pathogens including Klebsiella and Salmonella. These compounds inhibit chlamydia through a GrgA (General regulator of genes A) dependent mechanism..
Intellectual Property & Development Status:
Patent pending. Available for licensing and/or research collaboration.
TTO Home Page: https://techfinder.rutgers.edu
Name: Ryan Esculin
Title: Licensing Manager, Life Sciences
Department: Innovation Ventures