NOVEL CELL PENETRATING PEPTIDE FOR DELIVERY TO THE BRAIN

TECHNOLOGY DESCRIPTION
Buck investigators have developed a Zika virus-based peptide for penetrating the blood-brain barrier. This cell penetrating peptide can function as a delivery mechanism to transport proteins, peptides, nucleic acids (DNA, RNA, ssDNA, antisense oligonucliotides), organic compounds, and as a potential serotype for coating other viruses and nanoparticles. This technology has been validated in a mouse model. This presents an exciting opportunity to develop a novel therapeutic with a potential to treat neurodegenerative disease, as well as other diseases of the brain.

APPLICATIONS

  • Drug therapy for treatment of neurodevelopmental and neurodegenerative diseases, such as Alzheimer’s Disease, Parkinson’s Disease, ALS, Huntington’s disease, and others.• Drug therapy for treatment of certain brain tumors and cancers of the brain.• Drug therapy for targeting multiple organs with a single construct.

PATENT STATUSUS Patent IssuedUS11066448

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