Nanopore-based Sensors for Antibody Screening Applications

PRODUCT OPPORTUNITIES AND END-USE APPLICATIONS

  • Nanopore-based antibody screening system
  • Nanopore sensors for antibody detection and identification
  • Antibody screening in hybridoma-based antibody production
  • Real-time monitoring of antibody production in cell culture 

ADVANTAGES

  • Simple and fast antibody detection
  • Multiplex detection and antibody identification possible
  • Capable of identifying antibody subtypes in mixtures of antibodies such as polyclonal antibodies and blood samples.

TECHNOLOGY DESCRIPTION

This invention provides OmpG nanopore-based sensors for antibody screening applications. Each OmpG nanopore is engineered to contain a heterologous peptide sequence in one or more flexible loops of the nanopore, allowing for target-specific binding and detection.

ABOUT THE LEAD INVENTOR

Dr. Min Chen is an Asociate Professor in the Department of Chemistry at the University of Massachusetts Amherst. Her research group focuses on developing engineered protein pores for biosensing applications.

AVAILABILITY:

Available for Licensing and/or Sponsored Research

DOCKET:

UMA 22-057

PATENT STATUS:

Patent Pending

NON-CONFIDENTIAL INVENTION DISCLOSURE

LEAD INVENTOR:

Min Chen, Ph.D.

CONTACT:

This invention provides OmpG nanopore-based sensors for antibody screening applications. Each OmpG nanopore is engineered to contain a heterologous peptide sequence in one or more flexible loops of the nanopore, allowing for target-specific binding and detection.

Website

http://tto-umass-amherst.technologypublisher.com/tech/Nanopore-based_Sensors_for_Antibody_Screening_Applications

Contact Information

TTO Home Page: http://tto-umass-amherst.technologypublisher.com

Name: Ling Shen

Title: Senior Licensing Officer

Department: Technology Transfer Office

Email: lxshen@research.umass.udu

Phone: 413-545-5276