This novel therapeutic approach leverages structural nanotechnology to create a DNA nanostructure that acts as a customizable delivery vehicle for therapeutic molecules. The technology allows for a highly tunable and customizable multi-functional drug delivery platform that incorporates interchangeable i) small molecule therapeutics, ii) therapeutic oligonucleotides, and iii) targeting moieties on a single DNA-based nanostructure to specifically target and destroy tumor cells while leaving healthy tissue unharmed.
The folded DNA nanoparticle was shown to deliver clinically relevant dosages of daunorubicin in a human Acute Myeloid Leukemia multi-drug resistant cell line and refined drug release profiles. Combined with its fast self-assembly and stability in physiological conditions, this DNA nanostructure could be implemented to deliver a wide range of therapeutic agents and/or nucleic acids in a targetable manner.
- Rapid self-assembly of stable DNA origami nanostructures
- Scalable for commercial production
- Carrier for small molecule drugs, therapeutic oligonucleotides, and/or targeting/therapeutic antibodies
- Refined control of molecular placement for multi-functional modular devices (e.g. simultaneous, co-localized distribution) of therapeutic oligonucleotides and targeting molecules against a specific tumor antigen
- Refined loading of therapeutic agents
Stage of Development
- in vivo data in xenograft model of AML; data includes safety, immunogenicity, pharmacokinetics, distribution
- Precision medicine through antibody-targeting
- Customizable drug delivery platform
- Disease agnostic
TTO Home Page: https://tco.osu.edu/
Name: Panqing He