Mitigation of Negative Effects of Melphalan on Cardiomyocytes with N-acetyl-L-cysteine (NAC) Treatment

­ Application NAC (N-acetyl-L-cystine) as an antioxidant to reduce chemotherapy induced oxidative stress and cardiotoxicity. Key Benefits Mitigates cardiotoxic side effects of alkylating agent, melphalan in human cardiomyocytes. Market Summ…

Application
NAC (N-acetyl-L-cystine) is an antioxidant to reduce chemotherapy-induced oxidative stress and cardiotoxicity.

Key Benefits

  • Mitigates cardiotoxic side effects of an alkylating agent, melphalan in human cardiomyocytes.

Market Summary
Melphalan is a chemotherapeutic commonly used to treat various cancers including multiple myeloma, leukemia, and ovarian cancer, and is also administered in children receiving bone marrow transplants. Unfortunately, melphalan negatively affects cardiomyocytes (heart cells) which can cause cardiac diseases. Affected patients have an increased likelihood of ICU admission and longer hospital stays. Researchers at Emory University have found a method to mitigate the negative effects of melphalan on cardiomyocytes with N-acetyl-L-cysteine (NAC) treatment. This invention will contribute to the global cancer therapeutics market, which is projected to increase to $182 billion by 2023 with a CAGR of 7.3% from 2018-to 2023 (BCC Research PIIM177B).

Technical Summary
Researchers have developed a novel antioxidant to reduce the chemotherapy-induced oxidative stress and cardiotoxicity using N-acetyl-L-cystine (NAC). NAC is an antioxidant mostly used as a dietary supplement available at health food stores, but it is sometimes utilized to treat acetaminophen overdoses. Melphalan is a chemotherapeutic commonly used to treat a variety of cancers, however, it has been shown to affect heart cells which can lead to cardiac diseases negatively. The researchers demonstrated that melphalan acts on heart cells through oxidative stress, p53, and TGβ pathways. Under melphalan treatment researchers observed NAC mitigating cell loss and mitochondrial reactive oxygen species production in hiPSC-CMs, furthermore, NAC was observed to ameliorate the alteration of heart cell beating indexes caused by melphalan.

Developmental Stage
Early-stage. Publication: Melphalan Induces Cardiotoxicity Through Oxidative Stress in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells Stem Cell Res Ther. 2020; 11: 470

Website

https://emoryott.technologypublisher.com/techcase/20154

Contact Information

TTO Home Page: https://emoryott.technologypublisher.com

Name: Hyeon (Sean) Kim

Title: Licensing Associate

Email: hkim70@emory.edu

Phone: 404-727-7218