This invention provides methods for metabolic flux and kinetic measurement, imaging and microscopy. It is a method that generates an output representing in situ metabolic flux rates of a sample, where the sample is obtained from an individual to who one or more isotope-labeled precursors have been administered for a period of time sufficient for one or more isotope labels to become incorporated into the individual.
Measure metabolic rates of malignancies and their drug resistance.
Altered metabolic flux is pertain to the malignant phenotype and thus this method describes the relationship between signaling networks, drug resistance, metabolite transfer, microenvironment and metabolism.
Name: Craig Kennedy