Localization of Fluorescent Targets in Deep Tissue for Guiding Surgery

Imaging fluorescence through millimeters or centimeters of tissue has important in vivo applications, such as guided surgery and studying the brain. During fluorescence guided surgery, fluorescence of targeted contrast agents that have been absorbed by tumor cells help guide the removal of cancerous tissue. Current fluorescence guided surgery relies on standard imaging techniques that allow a surgeon to visually see fluorescence emission at the tissue surface. However, the depth, size, and shape of the tumor below the surface is not known.

Researchers at Purdue University have developed an optical imaging method and potential device for assisting with fluorescence guided surgery. This method allows for fast localization of fluorescent inhomogeneities in deep tissue. Experimental results show that the method was able to localize a tumor in a mouse as well as an inhomogeneity in a rat brain, thus demonstrating its applications in fluorescence guided surgery as well as studies of the brain. This device is not only a step forward in making guided surgery safer, but could be a gateway to learning more about the brain. Advantages: – Can determine size, shape, and location of a tumor Potential Applications: – Guiding surgery (Tumor localization) – Brain Studies




  • Can determine size, shape, and location of a tumor

Potential Applications

  • Guiding surgery (Tumor localization)
  • Brain Studies

Contact Information

Name: Patrick W Finnerty

Email: pwfinnerty@prf.org

Phone: 765-269-4080