Integration of Fluoroscopy Venogram and Myocardial Perfusion SPECT Image with Left-ventricular Contraction Sequence and Scar Distribution

3D SPECT/venogram analysis software for optimal placement of the LV lead used in cardiac resynchronization therapy (CRT).

Key Benefits

  • Integrating widely available myocardial perfusion SPECT imaging with fluoroscopy venogram accurately visualize the targeted myocardial wall.
  • The model incorporates LV contraction sequence and scar distribution to further optimize the LV placement target.

Market Summary
Heart failure (HF) is a pressing medical issue, and about 6.2 million adults in the United States have heart failure. Moreover, heart failure poses a great financial burden, costing the U.S. an estimated 30.7 billion in 2012. Cardiac resynchronization therapy (CRT) is commonly used to treat HF and improve cardiac function. Unfortunately, placing the leads for CRT often leads to failure as information about viable myocardium and delayed contraction is not available to implanting cardiologist. This invention addresses this problem with an improved technique to optimize placement of leads.

Technical Summary
The researcher at Emory University has created a medical imaging software to optimize placement of leads for cardiac resynchronization therapy (CRT) by using readily available fluoroscopy venogram and SPECT myocardial perfusion images to incorporate LV contraction sequence and scar distribution. This technique has been shown to greatly increase the success rate of implanting LV leads in target myocardial regions. The proof of concept study has demonstrated that the prototype used by the physicians allowed them to successfully implant the LV leads in target myocardial wall in roughly 90% of patients. CRT is used to treat the delay in ventricle contractions that occur in patients diagnosed with heart failure and shown promising results. The CRT placement device is a battery device placed under the skin with the purpose of creating small electric impulses through leads to the heart muscle these impulses cause the heart muscles to contract, which in turn cause the right and left ventricles to pump in unison resulting in improved cardiac function. An obstacle to mechanical resynchronization with CRT is the position the LV pacing lead due to a lack of information about viable myocardium and delayed contraction.

Developmental Stage
Validation using GUIDE CRT data.


Contact Information

TTO Home Page:

Name: Hyeon (Sean) Kim

Title: Licensing Associate


Phone: 404-727-7218