Instant Formation of Supramolecular Hydrogels by Short Peptide and Bioactive Small Molecules

  • This invention describes a novel approach to self-assemble peptides and relevant proteinepitopes intrigued by endogenous small bioactive molecules to develop various supramolecularstructures;\
  • The fast gelation is achieved by utilizing pyridoxal phosphate, pyridoxal, folinic acid, ATP, ADP,AMP and phosphorylated tyrosine to induce gelation process of a novel designed peptidesequence NapFFKKFKLKL
  • Based on the advantage of fast gelation, the system has great potentials in applications such aswould healing, tissue engineering, and 3D cell culture

Abstract

Instant Formation of Supramolecular Hydrogels by Short Peptide and Bioactive Small Molecules

Advantages

  • The invention would be more biocompatible and much faster comparing to other strategies forinstant gelation by using small endogenous molecules;
  • The present invention serves as an efficient method to design short peptides that adoptconformations such as helical and random-coil other than most common beta-sheet conformation;
  • The bioactive small molecules in this system can also serve as a cell compatible trigger forcrosslinking the pre-exist nanofibers of other peptides or drugs to form instant hydrogel.