Improved Hydrogels for Cell Culturing and Tissue Engineering

  • Technology Readiness Level: 3

Abstract

Researchers at Purdue University have developed a method to generate highly-accessible surface reactive sites on hydrogels. These surface sites can participate in thiol-ene click reactions, a broadly used class of reaction chemistry for biofunctionalization. Typically, reactive sites are distributed throughout hydrogels. The Purdue researchers’ method creates a high density of reactive sites on the surface, sites which are more readily accessible. The researchers’ method involves contacting a polymeric surface material with thiol-functionalized molecules to promote click reactions. The thiol-functionalized molecules can be cell adhesion molecules, allowing the support to be used as an engineered tissue.

Advantages

  • High surface density of reactive sites

Potential Applications

Engineered tissues

Contact Information

Name: Dipak Narula

Email: DNarula@prf.org

Phone: 765-588-1062