Hydrogel Surface With Anatomically-Accurate Anisotropic Nanometer-Scale Topography

Researchers at the University of California, Santa Barbara have developed substrates in polyacrylamide (PA) hydrogels that can accurately represent the in vitro microenvironment of human CMs with tunable stiffness properties and surface nanotopography. By mimicking a more physiologically relevant environment, companies can reduce their use of animal models and increase standardization in the development of new pharmacological drugs and personalized medicine. Beads and covalent linkers such as oHEA can be incorporated into the hydrogel to enable real-time displacement measurements and promote the adhesion of extracellular matrix proteins. These substrates are fabricated using widely accessible materials such as PDMS, glass, and PA hydrogels. This technology enables labs to incorporate nano-scale topography features into their substrates without additional expertise, access to a clean room facility, or other expensive equipment costs.



Contact Information

Name: Mary Raven

Email: raven@tia.ucsb.edu