High-Quality Methylxanthines Through Newly Engineered E. Coli Strain

­­HIGH-QUALITY METHYLXANTHINES THROUGH NEWLY ENGINEERING E. COLI STRAIN
Yielding More Biochemicals Through Greener Processes

THE PROBLEM

Pharmaceutical treatments of Parkinson’s disease, myopia, glaucoma, and macular degeneration are essential for patients’ continued quality of life; however, the vital compounds, paraxanthine and 7-methylxanthine, are currently produced using toxic chemicals under environmentally-unfriendly conditions. Due to this added hazard and low yield amounts, both compounds have exceedingly high retail values at approximately $1,400/gram for paraxanthine and $450/gram for 7-methylxanthine, resulting in higher medical costs and financial hardship to patients facing these chronic illnesses.

OUR SOLUTION

Researchers at The University of Alabama have developed a genetically engineered strain of E. coli that produces these essential compounds in larger amounts via a greener, non-toxic biological process, dramatically lowering costs. Using an abundant and inexpensive feedstock like caffeine, this novel synthesis of paraxanthine and 7-methylxanthine can significantly impact the pharmaceutical and cosmetic industries.

THE ADVANTAGES

  • Yields larger quantities of compounds
  • Green, environmentally-friendly process
  • More cost-effective
  • Biological production rather than chemical synthesis

­­HIGH-QUALITY METHYLXANTHINES THROUGH NEWLY ENGINEERED E. COLI STRAIN
Yielding More Biochemicals Through Greener Processes

THE PROBLEM

Pharmaceutical treatments of Parkinson's disease, myopia, glaucoma, and macular degeneration are essential for patients' continued quality of life; however, the vital compounds, paraxanthine, and 7-methylxanthine are currently produced using toxic chemicals under environmentally-unfriendly conditions. Due to this added hazard and low yield amounts, both compounds have exceedingly high retail values at approximately $1,400/gram for paraxanthine and $450/gram for 7-methylxanthine, resulting in higher medical costs and financial hardship to patients facing these chronic illnesses.

OUR SOLUTION

Researchers at The University of Alabama have developed a genetically engineered strain of E. coli that produces these essential compounds in larger amounts via a greener, non-toxic biological process, dramatically lowering costs. Using an abundant and inexpensive feedstock like caffeine, this novel synthesis of paraxanthine and 7-methylxanthine can significantly impact the pharmaceutical and cosmetic industries.

THE ADVANTAGES

  • Yields larger quantities of compounds
  • Green, environmentally-friendly process
  • More cost-effective
  • Biological production rather than chemical synthesis

Website:

http://ua.technologypublisher.com/technology/45830

Contact Information:

TTO Home Page: http://ua.technologypublisher.com

Name: Lynnette Scales

Title: Administrative Assistant

Department : Office for Innovation & Commercialization

Email: liscales@aalan.ua.edu

Phone : 348-5433