High Performance and Flexible Chemical And Bio Sensors Using Metal Oxide Semiconductors

UCLA researchers proposed and demonstrated a new simple method of one-step spin coating of aqueous In2O3 solution for fabricating ultrathin, sensitive In2O3 semiconductor-based FETs for use as chemical biosensors. The In2O3-based FETs had mobility and on/off ratios of ~20 cm2·V-1·s-1 and over 107, respectively. Specific chemical treatment and enzyme immobilization of the FETs facilitated pH and glucose detection, respectively, in real-time with linear and fast responses. The devices had excellent contact on highly rough artificial skin surfaces and an artificial eye surface.


UCLA researchers in the Department of Materials Science and Engineering have developed a simple method producing thin, sensitive In2O3-based conformal biosensors based on field-effect transistors using facile solution-based processing for future wearable human technologies as well as non-invasive glucose testing.




  • High sensitivity for non-invasive glucose level testing and other chemical and bio signals
  • Good FET device performance with mobility and on/off ratios of ~20 cm2·V-1·s-1 and over 107
  • Real-time pH and glucose detection with linear and fast responses
  • Compatible with flexible and wearable bio medical application on rough surface and skin
  • Low processing temperature (250oC)  
  • Compatible with large area processing that be integrated to roll-to-roll mass production for low cost process

Potential Applications

  • Non-invasive glucose level test using saliva or tear
  • Wearable biosensors for various targets such as heart rate and pH
    • Electronic skin
    • Disease diagnosis
    • Thermal regulation
    • Communication

Contact Information

Name: UCLA Technology Development Group

Email: ncd@tdg.ucla.edu

Phone: 310.794.0558