Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes

Application
Synthetic collagen-based biomaterials for therapeutic delivery or drug testing.

Key Benefits

  • Synthetic collagen substitute.
  • Capable of formulating into various structures.
  • Free of animal-based contaminants.
  • Able to be spatially patterned.

Market Summary
Synthetic collagen-based biomaterials have a wide range of uses. One such use is as a degradable bioplastic. Bioplastics in medicine sold 15,500 metric tons in 2018 and are expected to at a CAGR of 11% to 26,100 metric tons in 2023 (BCC Research PLS050E). Another use for this technology is a nanoengineered surface. The global market for nanoengineered surface was $402.9 million in 2017 and is expected to grow to $1.7 billion by 2022 at a CAGR of 31.7%. The biomedical market sector is expected to reach 40 million by 2022 at a CAGR of 36.3% from 2017-2022 (BCC Research AVM089B). Finally, this invention could potentially be characterized as a medical nanotechnology; the market of which was valued at $151.9 billion in 2016 and is expected to grow to $293.1 billion by 2022 at a CAGR of 14% (BCC Research HLC069D).

Technical Summary
Collagen is an ideal scaffold material for biomedical uses, however existing animal sources struggle with contamination and immunogenicity issues to address this issue the researchers developed a collagen substitute using synthesized collagen-mimetic peptides (CMPs). The core-shell assembly was constructed from a mixture of core nanosheet seeds and shell peptide monomers which are then heated at a temperature between the melting transition of core and shell triple helices and then cooled to temperatures below the melting transition of the shell peptide. Individual peptides form stable triple helices that do not form higher order structures. When the peptides are mixed at the appropriate pH nanotubes are formed in which the outer surface is defined by the charged triads, the inner surface is defined by the Pro-Hyp-Gly triads.

Developmental Stage
Prototype developed.

Publication:

  • Short Presentation: “Rational design and assembly of macroporous 1D nanotubes derived from collagen-mimetic peptides” at ACS Meeting, Orlando, FL. 3/31/19 – 4/4/19
  • Talk: Conticello, V. at Brandeis University. 9/14/2020

Website

https://emoryott.technologypublisher.com/techcase/19203

Contact Information

TTO Home Page: https://emoryott.technologypublisher.com

Name: Sat Balachander

Title: Licensing Associate

Email: sbalac5@emory.edu

Phone: (404) 727-4968