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Advantages
- Solves the difficulty of imposing enantio- and diastereocontrol over free radical-mediated bond forming processes
- Highly active at room temperature
- Fully genetically encoded and ready to function in bacterial cells and cell-free lysates
- Enables efficient preparation of chiral small-molecule agents
Potential Applications
- Pharmaceuticals and biotechnology
- Biomolecular science
- Agriculture
Additional Information
Background
Over the past three decades, the advent of directed evolution has enabled enhancements to catalytic activity and stereoselectivity through customized enzymes; demonstrating the potential of biocatalysis to revolutionize the practice of asymmetric synthesis. Until recently, however, the catalytic repertoire of enzymes has been mostly limited to reactions found in nature, posing constraints on the types of products available from enzyme catalysis. Furthermore, to date, a variety of catalysis modes discovered and optimized by synthetic chemists has remained out of reach of natural enzymes. It follows that bringing new catalytic functions to naturally-occurring enzymes can dramatically expand the repertoire of enzymology and generate novel biocatalysts applicable to fields such as pharmaceuticals and agrochemistry.
Tech ID/UC Case
32665/2021-975-0
Related Cases
2021-975-0
Contact Information
- Name: Mary Raven
- Title :
- Department :
- Email: raven@tia.ucsb.edu
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