Discovery of Gene Overexpression Combinations to Improve Therapeutic T Cell Constructs with Pooled CRISPR Knockin Screens

Abstract

Scientists at UCSF have developed a method for highly parallel testing of gene knockins/overexpression in combination with a cancer-specific T cell receptor (TCR) or chimeric antigen receptor (CAR). The method enables researchers to evaluate what constructs can improve anti-tumor efficacy of conventional T-cell therapies.

Website

https://techtransfer.universityofcalifornia.edu/NCD/32934.html?utm_source=AUTMGTP&utm_medium=webpage&utm_term=ncdid_32934&utm_campaign=TechWebsites

Contact Information

Name: Gemma Rooney

Email: Gemma.Rooney@ucsf.edu

Phone: 415-625-9093