Demineralized Bone Paper and Applications Thereof

PRODUCT OPPORTUNITIES

• Three-dimensional, living bone tissue grafts produced from stacked demineralized bone paper (DBP) for clinical applications

• DBP-based high-throughput and high-content assay systems for bone disease drug discovery

• Other DBP-containing products such as microfluidic bone marrow chips

PRODUCT OPPORTUNITIES

ADVANTAGES

Three-dimensional, living bone tissue grafts:

• Have well-defined and personalized shape and structure

• Can be rapidly generated

• Can easily incorporate drugs to promote bone tissue regeneration

DBP-based assay systems:

• High-throughput and high-content

• Simple and scalable

• Faithfully mimic the bone tissue remodeling process

• Can be easily humanized with human cells and other materials

TECHNOLOGY DESCRIPTION

This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.

ABOUT THE LEAD INVENTOR

Dr. Jungwoo Lee is an Associate Professor in the Department of Chemical Engineering and a BME Adjunct at the University of Massachusetts Amherst. His research focuses on translational biomaterials, bone marrow tissue engineering, microenvironment aging and cancer, and biomedical imaging.

AVAILABILITY:

Available for Licensing and/or Sponsored Research

DOCKET:

UMA 20-046

PATENT STATUS:

Patent Pending

NON-CONFIDENTIAL INVENTION DISCLOSURE

LEAD INVENTOR:

Jungwoo Lee, Ph.D.

CONTACT:

This invention provides structurally well-defined, three-dimensional bone tissue grafts produced from stacked demineralized bone paper (DBP), methods for treating a subject using such bone tissue grafts, methods for making DBP, and in vitro assay systems and methods for assaying the effect of an agent on bone development or health.

Website

http://tto-umass-amherst.technologypublisher.com/tech/Demineralized_Bone_Paper_and_Applications_Thereof

Contact Information

TTO Home Page: http://tto-umass-amherst.technologypublisher.com

Name: Ling Shen

Title: Senior Licensing Officer

Department: Technology Transfer Office

Email: lxshen@research.umass.udu

Phone: 413-545-5276