UCLA researchers have developed a method to synthesize a chemical library composed of unique molecules. Their ‘diversity-oriented synthesis’ technique was used to generate a 91-molecule library. The library consists of heterocyclic compounds composed of 16 distinct scaffolds and samples a large variety of structural and stereochemical conformations. They have used it to screen for inhibitors of invasion properties of breast cancer cells and have discovered 3 lead compounds. Additionally, the library has been screened for inhibitors of T cell exocytosis and for IFN-γ-like compounds.
Abstract
UCLA researchers in the Department of Chemistry and Biochemistry have developed a small molecule library consisting of a large variety of stereochemical variants.
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Advantages
- Samples a large number of chemical conformations and distinct scaffolds
- Improved synthesis method
Potential Applications
- High throughput screening for drug discovery
- High throughput screening for any chemical activity
- High throughput screening for any biological activity
Contact Information
Name: UCLA Technology Development Group
Email: ncd@tdg.ucla.edu
Phone: 310.794.0558