Compound Library Made Through Phosphine-Catalyzed Annulation/Tebbe/Diels-Alder Reaction

UCLA researchers have developed a method to synthesize a chemical library composed of unique molecules. Their ‘diversity-oriented synthesis’ technique was used to generate a 91-molecule library. The library consists of heterocyclic compound…

UCLA researchers have developed a method to synthesize a chemical library composed of unique molecules. Their ‘diversity-oriented synthesis’ technique was used to generate a 91-molecule library. The library consists of heterocyclic compounds composed of 16 distinct scaffolds and samples a large variety of structural and stereochemical conformations. They have used it to screen for inhibitors of invasion properties of breast cancer cells and have discovered 3 lead compounds. Additionally, the library has been screened for inhibitors of T cell exocytosis and for IFN-γ-like compounds.

Abstract

UCLA researchers in the Department of Chemistry and Biochemistry have developed a small molecule library consisting of a large variety of stereochemical variants.

Website

https://techtransfer.universityofcalifornia.edu/NCD/27511.html?utm_source=AUTMGTP&utm_medium=webpage&utm_term=ncdid_27511&utm_campaign=TechWebsites

Advantages

  • Samples a large number of chemical conformations and distinct scaffolds
  • Improved synthesis method

Potential Applications

  • High throughput screening for drug discovery
  • High throughput screening for any chemical activity
  • High throughput screening for any biological activity

Contact Information

Name: UCLA Technology Development Group

Email: ncd@tdg.ucla.edu

Phone: 310.794.0558