Combination of Phytoestrogen Plus Gut Bacteria as a Treatment for Multiple Sclerosis

  • Easily implemented treatment for MS and other neurological diseases.
  • Reduces inflammation and lessens disease severity.

Abstract

Technology DescriptionThe gut microbiota helps in maintaining our health by regulating various functions, including food metabolism, energy homeostasis, maintenance of the intestinal barrier, inhibition of colonization by pathogenic organisms and shaping of both the mucosal and systemic immune responses. Alteration of the gut microbiota and resulting changes in its metabolic network perturb this homeostasis, often leading to intestinal and systemic disorders including Multiple Sclerosis (MS) a chronic neuroinflammatory disease of the central nervous system (CNS) that results in sensory, motor, and/or cognitive dysfunction. Understanding the role gut microbes play in disease course may lead to possible interventions of diet, probiotics, and/or advanced combinatorial therapies for patients with MS.Inventors at the University of Iowa have developed a combination therapy that can help reduce the severity and prevent the onset of MS. The inventors have created a method of modulating the diet and gut microbiota to help reduce inflammation, lessen disease severity and progression, and may also help prevent the onset of MS. Specifically, they have discovered that certain metabolites produced by a particular set of gut microbes, in the presence of a diet rich in phytoestrogens, dampens the inflammatory response and suppresses the disease in a murine model. Therefore, specifically modulating the diet and promoting the presence of certain gut microbes is a novel approach to treating MS and may potentially prevent the onset or reduce severity of the disease. As gut dysbiosis and inflammation is linked with multiple diseases the combination of diet plus specific gut bacteria may be used to treat other inflammatory and neurological diseases as well.UIRF Case No. 2023-009Stage of DevelopmentThe intervention has been tested in an experimental autoimmune encephalomyelitis murine model, a commonly accepted model for studying MS.

Advantages

  • Novel intervention that can be combined into an oral supplement.
  • Safe and easily implemented by patients.
  • May be formulated for sustained delivery.

Contact Information

Name: Kellen Sensor

Email: kellen-sensor@uiowa.edu

Phone: 319.335.4546