Applications:
Drug discovery
A direct evolution of proteins
Epitope mapping
Modulation of enzyme activity
Technology Overview:
Highly diverse (~710) camelid single-domain antibody phage display library constructed from the blood, bone marrow, and spleens of a dozen llamas and alpacas. This library has been validated in Professor LeBeau’s lab, positively identifying 6-7 binders to specific proteins. This research tool can be used to isolate novel single-domain antibody fragments against recombinant proteins and cell lines for various biotechnology applications in industry and academia. In fact, this library has yielded a possible drug called Nanosota-1C-Fc, which has demonstrated preventive and therapeutic efficacy against live SARS-CoV-2 infection in both hamster and mouse models ( see https://doi.org/10.7554/eLife.64815)
Desired Partnerships:
This phage library is fully developed and available for license. Please contact our office to learn more.
Researchers:
Aaron LeBeau, PhD Assistant Professor, Department of Pharmacology
Abstract:
Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target
Website:
https://license.umn.edu/product/camelid-single-domain-antibody-phage-display-library
Contact Information:
Name: Rayla Vilar
Email: pinto115@umn.edu
Phone: 5158173606