Camelid single domain antibody phage display library

Applications Drug discovery Direct evolution of proteins Epitope mapping Modulation of enzyme activity Technology Overview Highly diverse (~710) camelid single domain antibody phage display library constructed from the blood, bone marro…

Applications:
Drug discovery
A direct evolution of proteins
Epitope mapping
Modulation of enzyme activity


Technology Overview:
Highly diverse (~710) camelid single-domain antibody phage display library constructed from the blood, bone marrow, and spleens of a dozen llamas and alpacas. This library has been validated in Professor LeBeau’s lab, positively identifying 6-7 binders to specific proteins. This research tool can be used to isolate novel single-domain antibody fragments against recombinant proteins and cell lines for various biotechnology applications in industry and academia. In fact, this library has yielded a possible drug called Nanosota-1C-Fc, which has demonstrated preventive and therapeutic efficacy against live SARS-CoV-2 infection in both hamster and mouse models ( see https://doi.org/10.7554/eLife.64815)

Desired Partnerships:
This phage library is fully developed and available for license. Please contact our office to learn more.

Researchers:
Aaron LeBeau, PhD Assistant Professor, Department of Pharmacology

Abstract:

Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target

Website:

https://license.umn.edu/product/camelid-single-domain-antibody-phage-display-library

Contact Information:

Name: Rayla Vilar

Email: pinto115@umn.edu

Phone: 5158173606