Branched Nanochannel devices for detection and sorting of Nucleic Acids

The Problem:
Although methods to edit DNA have increased in recent years, there is no method to effectively screen edited DNA. Traditionally, edited DNA is placed into bacteria to see the effects of the DNA edit. Thus, to determine if the editing worked the bacteria must be grown and then analyzed to determine if the effect was seen. If not, then the editing must go back to square one.

The Solution:
Researchers at The University of Alabama have developed a method that enables the detection and screening of an edited gene on DNA at a molecular level. This method eliminates the need to utilize bacteria to determine an edit in DNA. By utilizing a branched nanochannel, researchers are able to analyze the DNA to detect the editing. This allows for an easier and faster method to detect the edited DNA.

Benefits:

  • Accurate and quick method to identify single molecules in a sequence.
  • Able to determine location of target genes on DNA molecules.
  • Able to determine presence of edited genes in a more efficient manner.

The University of Alabama Research Office of Innovation and Commercialization (OIC) is a non-profit corpo­ration that is responsible for commercializing University of Alabama technologies and for supporting University research. At OIC, we seek parties that are interested in learning more about our technologies and commercialization opportunities, and we welcome any inquiries you may have.

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Name: Lynnette Scales

Title: Administrative Assistant

Department: Office for Innovation & Commercialization

Email: liscales@ua.edu

Phone: (205) 348-5433