The disclosed invention is a 3D biocompatible and biodegradable scaffold that can be implanted together with stem cells to promote neuroregeneration and long-term functional recovery of SCI. The inventor’s scaffolds can recapitulate the most important aspects of a healthy spinal cord in terms of the internal structure, shape of different areas, textures, and stiffness, and thus can produce optimal effects for the grafted cells to survive and flourish in the hostile environment during the acute and subacute post-SCI phases and promote the communications between the host and implanted cells, and ultimately, lead to functional recovery. Problem Addressed by Claimed Invention A major hurdle for cell-based therapy after SCI is the insufficient efficacy and poor survivability of the grafted stem cells. This is due to the hostile environment at the site of injury during the acute phase of SCI, which does not allow survival and development of proper functions of the grafted cells. Engineered 3D tissue scaffolds can be used to bridge the wound, inhibit the formation of nerve scars, and physically guide the axons at both ends of the injury to reconnect. They can also be used as carriers of bioactive components or cells to form biofunctional scaffolds to inhibit secondary damage or provide the driving force for nerve regeneration. Therefore, combining 3D tissue scaffolds with the fine-tuned grafted cells will enable promising treatment solutions to SCI.
- Superior control of materials and structural features
Spinal cord injury repair
Name: Technology Ventures