BIOMARKERS FOR SENESCENT CELLS

TECHNOLOGY DESCRIPTIONThe presence of senescent cells in an individual is thought to contribute to aging and aging-related dysfunction. Senescent cells accumulate in tissues and organs of individuals as they age and are found at sites of age-related pathologies. Moreover, there is growing evidence that senescent cells drive a growing and diverse number of age-related diseases, including those of tumor progression. There is already a number of drugs in development that selectively target senescent cells and eliminate them (senolytic drugs) leading to a need to be able to assess whether and to what extent a senolytic drug is efficacious. The present Buck invention provides a pathway towards doing so.

APPLICATIONS

  • Diagnostic for measuring elevated senescent cells in a patient.• Companion diagnostic for senolytic drugs.• Method of treating pathologies associated with elevated senescent cells by administering a senolytic.

PATENT STATUS

Patent pending in US and other jurisdictions

Published Application

LEAD INVESTIGATOR
Judith Campisi, Ph.D.

Website

https://thebuck.wpenginepowered.com/wp-content/uploads/2022/08/NCD-BI348-Campisi.pdf