Artificial Extracellular Matrix (ECM) to Direct Cell Adhesion and Growth

  • Technology Readiness Level: 3
  • Analytical and experimental critical function and/or characteristic proof-of concept

Abstract
Researchers at Purdue University have developed a novel method for directing cell adhesion and growth. This method uses ultrathin striped molecular films on soft materials and improves on the scale limitations imposed by the current lithographic technology, while diversifying chemistries that can be patterned to direct cell growth. Taken together, the features of this technology can be used to design artificial ECM. This technology has been validated using a murine myoblast model; cells adhere and proliferate extensively on the ultrathin striped films, which display patterned chemistries designed to mimic biological ligand clustering. Potential applications of this technology include regenerative medicine, studying ligand clustering and understanding progression of diseases.

Contact Information

Name: Dipak Narula

Email: DNarula@prf.org

Phone: 765-588-1062