UCLA researchers have developed a cell-free approach for production of chemicals. Their method involves combining different metabolic pathways in vitro. They have optimized the method to include a ‘molecular rheostat’ that regulates and recycles ATP, an expensive cofactor utilized in nearly all bio-based chemical production methods. They have utilized the rheostat for production of isobutanol from glucose and obtained a two-fold increase with yields of up to 24 g/L.
UCLA researchers in the Department of Chemistry and Biochemistry have developed a system for regulation of cofactors in cell free biochemical production.
- Can be scaled up for industrial applications
- Regulates and recycles ATP
- 91% yield obtained
- Completely in vitro approach
- Production of isobutanol
- Production of bioplastics
- Production of biofuels
Name: UCLA Technology Development Group