A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules

­Application
A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC).

Market Summary
The global market for nanomanipulators indicates that the nanoscale market value will grow to $26.8 million by 2028 with a CAGR of 5.4% from 2023-2028 (BCC Research). Moreover, the market for nanosensors is much larger, with the market value expected to reach $1.625 billion in 2028 with a CAGR of 10.7% from 2023-2028 (BCC Research NAN062A). If this invention could be used as a nanosensor, this invention would have much greater market potential. There is strong but limited competition in this market.

Key Benefits

  • Particles can be immobilized onto virtually any type of support.
  • Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands.
  • Ability to have multiple PFC’s measuring associated DNA unfolding at the same time.

Technical Summary
Researchers at Emory have developed a method for the study of mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC). The method consists of using a responsive polymer such as light or heat to manipulate the molecules found between substrates. The technology for the method is based on a platform-bound ligand that is fused to domains that being a fluorophore and a quencher separated by a PEG (polyethylene glycol) linker. The fluorophore/ligand is placed in proximity to the quenching signal in the absence of binding, furthermore, there is no fluorescence.

Developmental Stage
Prototype developed.

Publication:
Publicly presented on March 28, 2018.

Website

https://emoryott.technologypublisher.com/techcase/18082

Contact Information

TTO Home Page: https://emoryott.technologypublisher.com

Name: Catherine Murari-Kanti

Title: Licensing Associate

Email: cmurari@emory.edu

Phone: (404) 727-0057