A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules

A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC).

Market Summary
The global market for nanomanipulators indicates that the nanoscale market value will grow to $26.8 million by 2028 with a CAGR of 5.4% from 2023-2028 (BCC Research). Moreover, the market for nanosensors is much larger, with the market value expected to reach $1.625 billion in 2028 with a CAGR of 10.7% from 2023-2028 (BCC Research NAN062A). If this invention could be used as a nanosensor, this invention would have much greater market potential. There is strong but limited competition in this market.

Key Benefits

  • Particles can be immobilized onto virtually any type of support.
  • Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands.
  • Ability to have multiple PFC’s measuring associated DNA unfolding at the same time.

Technical Summary
Researchers at Emory have developed a method for the study of mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC). The method consists of using a responsive polymer such as light or heat to manipulate the molecules found between substrates. The technology for the method is based on a platform-bound ligand that is fused to domains that being a fluorophore and a quencher separated by a PEG (polyethylene glycol) linker. The fluorophore/ligand is placed in proximity to the quenching signal in the absence of binding, furthermore, there is no fluorescence.

Developmental Stage
Prototype developed.

Publicly presented on March 28, 2018.



Contact Information

TTO Home Page: https://emoryott.technologypublisher.com

Name: Catherine Murari-Kanti

Title: Licensing Associate

Email: cmurari@emory.edu

Phone: (404) 727-0057