2022-058 – Multifunctional nanocomposite of clay, silver and tannic acid for antibacterial applications

  • Multifunctional nanocomposite material that shows antibacterial therapeutic qualities
  • Nanocomposite showed anti-efflux, antibiofilm properties, could induce oxidative stress, and cause loos of bacterial membrane potential and integrity
  • Nanocomposite could overcome multi-drug resistance

Abstract

This innovation is related to the synthesize of a nanocomposite material showing multifunctionality for its applications as antibacterial therapeutic for animal/poultry agriculture as well as for preparing functional food packaging material. The nanocomposite showed anti-efflux, anti-biofilm properties, could induce oxidative stress, and cause loss of bacterial membrane potential and integrity. Therefore, the nanocomposite could overcome multi-drug resistance and virulence characteristics as exemplified in a multi-drug resistant Salmonella enterica serovar Typhimurium isolated from an infected swine and cured gastrointestinal infection in the Caenorhabditis elegans model. Desirable therapeutic characteristics and affordability of this combination therapy with natural chemistry propose its application as a nanotherapeutic against recalcitrant bacterial infections in livestock. The nanocomposite when incorporated in food packaging material will serve functions of preventing microbial growth and spoilage of stored food, act as an antioxidant to enhance shelf-life of packaged food and enhance the gas and moisture barrier properties of plastic/paper based food packaging materials.

Advantages

· The nanocomposite’s natural chemistry makes the nano-enabled drug formulations environmentally safer, economical, and biocompatible in comparison to heavy doses of antibiotics required for curing infections.

Potential Applications

· Antimicrobial resistance (AMR) is one of the top ten health threats worldwide as declared by the World Health Organization with extensive antibiotic use in animal farms being a drive for the emergence of AMR.

Approximately 70% of the antibiotics used in animal agriculture are medically important to humans. AMR from animal farms can get transmitted to humans.

Using this nanocomposite could help overcome multi-drug resistant bacteria

Can be incorporated in food packaging material to assist in preventing microbial growth and food spoilage – therefore enhancing produce shelf-life.

Contact Information

Name: Sarah Butcher

Email: sarah.butcher@mcgill.ca

Phone: 514-396-1637