2021-3D Scaffolding System for ex vivo Cell and Tissue Growth

Increased permeability throughout concentrated cell/tissue in ex vivo scaffoldsEnhanced movement of nutrients, cell signals, and waste products among cellsVersatile model system with various applications in engineered tissues
  • Increased permeability throughout concentrated cell/tissue in ex vivo scaffolds
  • Enhanced movement of nutrients, cell signals, and waste products among cells
  • Versatile model system with various applications in engineered tissues

Abstract:

The major limitation of the ex vivo scaffolding system is the lack of transport properties. Fluid materials can’t be transferred once cell growth reaches a certain thickness or density. However, a high concentration of cells can more closely mimic an in vivo tissue environment. To solve this problem of ex vivo tissue growth limit, UGA inventors have developed a new 3D scaffolding system that is able to facilitate transportation of fluids among cells. This system is comprised of a base material (hydrogel or alginate sponge) with embedded wicking fibers which enhance the diffusion of fluid materials via capillary action. With nutrients and biomolecules being transferred freely in the system, it can better mimic the in vivo environment with high cell density. A variety of cells can be supported by this system, including a portion of a tissue explant.

Advantages:

-

Potential Applications:

In 2017, the global tissue engineering and regeneration market was valued at $18.3 billion. Cell Therapy and Tissue Engineering are major components of this market, which requires sustained growth for cells and tissues. Having a system to ensure their development with sufficient fluid transfer is key. This technology can be applied to various cell types. In 2017, the global market for musculoskeletal applications was over $6 billion, with wound healing accounting for over $5 billion. Other growing fields for this market include oncology and neurology.

Additional Information:

-

Website

https://uga.flintbox.com/technologies/BE8D5B747C014A11B655BE41B494848A

Contact Information:

  • Name : "" ""
  • Title :
  • Department :
  • Email: ""
  • Phone : ""
  • Address :